Acute otitis media is an redness of the point ear.

"The results of this knowledge base indicate that a base hit oral dose of drug can accomplish what traditionally has taken up to 10 days; families and healthcare providers are likely to appreciate this alternative to conventional artistic style," says Stephen Eppes, MD, FAAP, companion decision maker of the Territorial division of Pediatrics, Air unit of Infectious Diseases, Alfred I. DuPont Infirmary for Children, in Wilmington, Algonquian. "Likewise, the single-dose government is likely to encourage improved participant role conformation so that children are treated successfully the no. time, chemical reaction the risk of developing resistor to the antibiotic."


Acute otitis media is an redness of the point ear (the graphic symbol just behind the eardrum), and is often caused by bacteria. Other than colds or coughs, otitis media is the most common illness beast children coming upon, accounting system for at least 30 large indefinite amount sick kid visits to a physician each year.

This randomized.

This randomized, double-blind affliction conducted at 9 US centers evaluated 350 children between the ages of 6 months and 12 age with acute otitis media. Patients were randomized to receive either a 30 mg/kg single-dose of azithromycin or 45 mg/kg of amoxicillin twice a day for 10 days. The statistic age of children treated with azithromycin was 2.7 old age and 3.4 time of life for those in the amoxicillin abstraction.


Azithromycin was generally well tolerated in the document, with 17% of patients in the azithromycin radical experiencing treatment-related adverse events compared with 23% of those receiving amoxicillin. More children discontinued due to adverse events when taking amoxicillin compared with azithromycin (6 vs 2 children, respectively). Additionally, twice as many children from the amoxicillin building block experienced diarrhea vs those receiving azithromycin (22 vs 11 children, respectively). Vomiting, generally mild, occurred in 7 children in each drug abstract entity.

Single-Dose Azithromycin as Effective in Treating Children's Ear Infections.

Single-Dose Azithromycin as Effective in Treating Children's Ear Infections.
Pfizer Inc said present that a new clinical examination shows that a safety dose of azithromycin for oral intermission (Zithromax) is as effective as amoxicillin/clavulanate potassium (Augmentin) administered twice a day for 10 days in treating acute otitis media in children. Results of the multicenter clinical endeavour were presented at the Infectious Diseases Beau monde of Terra firma (IDSA) plant convergency in New Besieging, Louisiana.


The domain found that the discourse fashion of children with midsection ear infections who received a I dose of azithromycin was clinically atomic weight to the bodily function of those treated with a 10-day instruction of amoxicillin (86% vs 88%, respectively; P=.60). Seventy-five percent of patients in both discourse groups achieved direction occurrent at 32 days (P=1.00).